Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genome editing tool
artificial restriction enzyme |
| gptkbp:alternativeTo |
gptkb:CRISPR-Cas9
gptkb:TALEN |
| gptkbp:appliesTo |
animal genome editing
plant genome editing human gene therapy |
| gptkbp:composedOf |
zinc finger DNA-binding domain
DNA-cleavage domain |
| gptkbp:deliveredBy |
gptkb:virus
gptkb:gene plasmid |
| gptkbp:developedBy |
gptkb:Aaron_Klug
1990s Carlos F. Barbas III |
| https://www.w3.org/2000/01/rdf-schema#label |
Zinc finger nuclease
|
| gptkbp:mechanismOfAction |
induces double-strand breaks in DNA
|
| gptkbp:patent |
gptkb:Sangamo_Therapeutics
|
| gptkbp:relatedTo |
gptkb:FokI_endonuclease
zinc finger protein |
| gptkbp:requires |
custom protein engineering
|
| gptkbp:riskFactor |
off-target effects
cytotoxicity |
| gptkbp:target |
specific DNA sequences
|
| gptkbp:usedFor |
genome editing
gene knockout gene correction gene insertion |
| gptkbp:usedIn |
biomedical research
functional genomics |
| gptkbp:bfsParent |
gptkb:Transcription_Activator-Like_Effector_Nuclease
|
| gptkbp:bfsLayer |
7
|