Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredBy |
gptkb:Harold_Varmus
|
| gptkbp:encodedBy |
gptkb:WNT_genes
|
| gptkbp:enemyOf |
gptkb:DKK1
gptkb:WIF1 gptkb:sFRP |
| gptkbp:firstDescribed |
1982
|
| gptkbp:foundIn |
animals
humans invertebrates vertebrates |
| gptkbp:function |
cell proliferation
cell migration cell signaling stem cell maintenance cell polarity regulation of embryonic development |
| gptkbp:involvedIn |
gptkb:Wnt_signaling_pathway
canonical Wnt pathway non-canonical Wnt pathway |
| gptkbp:modulatedBy |
palmitoylation
Porcupine enzyme glycosylation |
| gptkbp:molecularWeight |
~40 kDa
|
| gptkbp:nameOrigin |
wingless + int-1
|
| gptkbp:numberOfGenes |
19
|
| gptkbp:numberOfGenesInDrosophila |
7
|
| gptkbp:numberOfGenesInMice |
19
|
| gptkbp:orthologIn |
int-1 (mouse)
wingless (Drosophila) |
| gptkbp:postTranslationalModification |
palmitoylation
glycosylation |
| gptkbp:proteinFamily |
gptkb:WNT_gene_family
|
| gptkbp:recipient |
gptkb:Frizzled_receptor
gptkb:LRP5/6 |
| gptkbp:relatedTo |
gptkb:cancer
colorectal cancer developmental disorders bone formation neurogenesis oncogenesis planar cell polarity |
| gptkbp:role |
organogenesis
tissue regeneration heart development hematopoiesis adipogenesis axis formation hair follicle development limb development synapse formation neural crest development bone homeostasis stem cell niche maintenance |
| gptkbp:structure |
secreted glycoprotein
cysteine-rich |
| gptkbp:bfsParent |
gptkb:Frizzled/LRP5/6_receptor_complex
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
Wnt protein
|