|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:category
|
Analgesics (for some agents)
Central nervous system agents
Psychotropic medications
|
|
gptkbp:contraindication
|
Liver disease (for some agents)
Pregnancy (for some agents)
|
|
gptkbp:discoveredIn
|
19th century
|
|
gptkbp:drugInteraction
|
gptkb:beer
gptkb:Warfarin
Oral contraceptives
Other antiepileptics
|
|
gptkbp:example
|
gptkb:Phenobarbital
gptkb:Carbamazepine
gptkb:Ethosuximide
gptkb:Gabapentin
gptkb:Lamotrigine
gptkb:Levetiracetam
gptkb:Phenytoin
gptkb:Pregabalin
gptkb:Topiramate
gptkb:Valproic_acid
|
|
gptkbp:excretion
|
gptkb:Kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Anticonvulsants
|
|
gptkbp:mechanismOfAction
|
Enhance GABA activity
Inhibit calcium channels
Inhibit sodium channels
Stabilize neuronal membranes
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:pregnancyCategory
|
Varies by drug
|
|
gptkbp:prescribes
|
gptkb:Neurologist
gptkb:Primary_care_physician
Psychiatrist
|
|
gptkbp:regulates
|
Prescription only
Seizure threshold
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Rectal
Intravenous
|
|
gptkbp:sideEffect
|
gptkb:Nausea
gptkb:Ataxia
Weight loss
Weight gain
Dizziness
Rash
Drowsiness
Liver toxicity
|
|
gptkbp:usedFor
|
gptkb:Bipolar_disorder
Epilepsy
Anxiety disorders
Neuropathic pain
|
|
gptkbp:bfsParent
|
gptkb:D002409
|
|
gptkbp:bfsLayer
|
6
|