Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:discoveredBy |
gptkb:James_C._Wang
|
| gptkbp:discoveredIn |
1971
|
| gptkbp:EC_number |
5.99.1.2
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
alters DNA supercoiling
relieves DNA torsional strain |
| gptkbp:GO_term |
gptkb:GO:0003916
|
| gptkbp:hasType |
gptkb:Type_II_topoisomerase
gptkb:Type_I_topoisomerase |
| https://www.w3.org/2000/01/rdf-schema#label |
Topoisomerase
|
| gptkbp:importantFor |
DNA replication
chromosome segregation DNA transcription |
| gptkbp:presentIn |
gptkb:Bacteria
humans archaea |
| gptkbp:relatedTo |
gptkb:Etoposide
gptkb:DNA_gyrase gptkb:Camptothecin gptkb:Topoisomerase_inhibitor |
| gptkbp:target |
antibiotics
anticancer drugs |
| gptkbp:Type_I_topoisomerase |
cuts one DNA strand
|
| gptkbp:Type_II_topoisomerase |
cuts both DNA strands
|
| gptkbp:bfsParent |
gptkb:Enzymes
|
| gptkbp:bfsLayer |
6
|