Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:tryptophan_pyrrolase
gptkb:TDO |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:depression neurodegenerative disorders |
| gptkbp:catalyzes |
oxidation of L-tryptophan to N-formylkynurenine
|
| gptkbp:cofactor |
hemoglobin
|
| gptkbp:discoveredBy |
1936
|
| gptkbp:EC_number |
1.13.11.11
|
| gptkbp:foundIn |
liver
|
| gptkbp:gene |
gptkb:TDO2
|
| gptkbp:GO_term |
GO:0004833
|
| https://www.w3.org/2000/01/rdf-schema#label |
Tryptophan 2,3-dioxygenase
|
| gptkbp:inhibitedBy |
alpha-methyltryptophan
nicotinamide |
| gptkbp:organism |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:pathway |
kynurenine pathway
|
| gptkbp:product |
N-formylkynurenine
|
| gptkbp:regulates |
induced by glucocorticoids
induced by tryptophan |
| gptkbp:requires |
molecular oxygen
|
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
L-tryptophan
|
| gptkbp:UniProtID |
P48775
|
| gptkbp:bfsParent |
gptkb:TDO
|
| gptkbp:bfsLayer |
5
|