|
gptkbp:instanceOf
|
natural product
alkaloid
topoisomerase inhibitor
|
|
gptkbp:ATCCode
|
L01XX17
|
|
gptkbp:CASNumber
|
7689-03-4
|
|
gptkbp:category
|
alkaloid
antineoplastic agent
lactone
quinoline
plant alkaloid
|
|
gptkbp:chemicalFormula
|
C20H16N2O4
|
|
gptkbp:color
|
yellow
|
|
gptkbp:discoveredBy
|
gptkb:Mansukh_C._Wani
Monica M. Wall
Wallace H. Bollinger
|
|
gptkbp:discoveredIn
|
1966
|
|
gptkbp:foundIn
|
gptkb:Camptotheca_acuminata
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Camptothecin
|
|
gptkbp:IUPACName
|
(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
|
|
gptkbp:mechanismOfAction
|
inhibits DNA topoisomerase I
|
|
gptkbp:meltingPoint
|
267–269 °C
|
|
gptkbp:molecularWeight
|
348.36 g/mol
|
|
gptkbp:notableDerivative
|
gptkb:irinotecan
gptkb:topotecan
|
|
gptkbp:predecessor
|
gptkb:SN-38
gptkb:irinotecan
gptkb:topotecan
BMS-184476
BMS-275183
S-9
TAS-103
belotecan
diflomotecan
exatecan
gimatecan
lurtotecan
namitecan
rubitecan
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL418
24360
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
myelosuppression
|
|
gptkbp:solubility
|
poorly soluble in water
|
|
gptkbp:source
|
gptkb:Camptotheca_acuminata
|
|
gptkbp:structureType
|
pentacyclic quinoline alkaloid
|
|
gptkbp:toxicity
|
high
|
|
gptkbp:UNII
|
8M8G366C5K
|
|
gptkbp:usedAs
|
anticancer agent
|
|
gptkbp:bfsParent
|
gptkb:Mansukh_C._Wani
|
|
gptkbp:bfsLayer
|
6
|