|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:activatedBy
|
endothelial cell survival
vascular maturation
|
|
gptkbp:alternativeName
|
CD202B
TEK receptor tyrosine kinase
|
|
gptkbp:associatedWith
|
gptkb:cancer
sepsis
venous malformations
|
|
gptkbp:binds
|
gptkb:angiopoietin-2
gptkb:angiopoietin-1
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:component
|
integral component of plasma membrane
|
|
gptkbp:discoveredBy
|
Sato et al.
|
|
gptkbp:encodedBy
|
gptkb:TEK_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000120156
7010
|
|
gptkbp:expressedIn
|
embryonic development
blood vessels
|
|
gptkbp:foundIn
|
endothelial cells
|
|
gptkbp:function
|
transmembrane receptor protein tyrosine kinase activity
regulation of angiogenesis
maintenance of vascular integrity
|
|
gptkbp:GOProcess
|
blood vessel morphogenesis
|
|
gptkbp:HGNC_ID
|
11742
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Tie2 receptor
|
|
gptkbp:inhibitedBy
|
gptkb:rebastinib
trebananib
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9q21
|
|
gptkbp:molecularWeight
|
~140 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_hemorrhagic_telangiectasia
venous malformation, multiple cutaneous and mucosal (VMCM)
|
|
gptkbp:OMIM
|
600221
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
2GY7
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:UniProtID
|
gptkb:Q02763
|
|
gptkbp:bfsParent
|
gptkb:angiopoietin-2
|
|
gptkbp:bfsLayer
|
7
|