Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:approvedTherapy |
gptkb:entrectinib
gptkb:larotrectinib |
| gptkbp:associatedWith |
gptkb:cancer
|
| gptkbp:cause |
constitutive activation of TRK signaling
|
| gptkbp:diagnosedBy |
gptkb:fluorescence_in_situ_hybridization
next-generation sequencing immunohistochemistry |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:foundIn |
solid tumors
pediatric cancers adult cancers |
| gptkbp:involveGene |
gptkb:NTRK1
gptkb:NTRK2 gptkb:NTRK3 |
| gptkbp:ledTo |
oncogenic transformation
|
| gptkbp:mechanismOfAction |
gptkb:chromosomal_rearrangement
|
| gptkbp:target |
gptkb:entrectinib
gptkb:larotrectinib |
| gptkbp:WHOClassification |
NTRK-rearranged neoplasms
|
| gptkbp:bfsParent |
gptkb:Larotrectinib
|
| gptkbp:bfsLayer |
7
|
| http://www.w3.org/2000/01/rdf-schema#label |
TRK fusion proteins
|