Statements (23)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:protein
|
gptkbp:approvedTherapy |
gptkb:entrectinib
gptkb:larotrectinib |
gptkbp:associatedWith |
gptkb:cancer
|
gptkbp:cause |
constitutive activation of TRK signaling
|
gptkbp:diagnosedBy |
gptkb:fluorescence_in_situ_hybridization
next-generation sequencing immunohistochemistry |
gptkbp:firstDescribed |
1980s
|
gptkbp:foundIn |
solid tumors
pediatric cancers adult cancers |
https://www.w3.org/2000/01/rdf-schema#label |
TRK fusion proteins
|
gptkbp:involveGene |
gptkb:NTRK1
gptkb:NTRK2 gptkb:NTRK3 |
gptkbp:ledTo |
oncogenic transformation
|
gptkbp:mechanismOfAction |
chromosomal rearrangement
|
gptkbp:target |
gptkb:entrectinib
gptkb:larotrectinib |
gptkbp:WHOClassification |
NTRK-rearranged neoplasms
|
gptkbp:bfsParent |
gptkb:Larotrectinib
|
gptkbp:bfsLayer |
7
|