|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
VSIG9
VSTM3
WUCAM
|
|
gptkbp:associatedWith
|
immunotherapy
|
|
gptkbp:binds
|
gptkb:CD112
CD155
|
|
gptkbp:cellSurfaceMarker
|
true
|
|
gptkbp:discoveredIn
|
2009
|
|
gptkbp:domain
|
ITIM motif
IgV domain
|
|
gptkbp:downregulatedIn
|
immune cell activation
|
|
gptkbp:encodedBy
|
TIGIT gene
|
|
gptkbp:Entrez_Gene_ID
|
201633
|
|
gptkbp:expressedIn
|
gptkb:NK_cells
gptkb:T_cells
|
|
gptkbp:fullName
|
T cell immunoreceptor with Ig and ITIM domains
|
|
gptkbp:function
|
immune checkpoint receptor
|
|
gptkbp:gene
|
gptkb:TIGIT
|
|
gptkbp:HGNC_ID
|
HGNC:24621
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIGIT
|
|
gptkbp:inhibitedBy
|
T cell activation
NK cell cytotoxicity
|
|
gptkbp:inhibitoryReceptor
|
true
|
|
gptkbp:involvedIn
|
gptkb:disease
autoimmune disease
tumor immune evasion
|
|
gptkbp:length
|
244 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
|
|
gptkbp:modulatedBy
|
cytokine production
|
|
gptkbp:molecularWeight
|
~26 kDa
|
|
gptkbp:OMIM
|
612876
|
|
gptkbp:phosphorylates
|
ITIM motif
|
|
gptkbp:regulates
|
immune response
|
|
gptkbp:relatedTo
|
gptkb:CTLA-4
gptkb:CD226
gptkb:PD-1
CD96
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
monoclonal antibodies
|
|
gptkbp:therapeuticArea
|
true
|
|
gptkbp:UniProtID
|
Q495A1
|
|
gptkbp:bfsParent
|
gptkb:CD155_(PVR)
gptkb:immunoglobulin_superfamily
|
|
gptkbp:bfsLayer
|
7
|