|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
mitochondrial RNA polymerase
mtRNAP
|
|
gptkbp:alternativeSplicing
|
no known isoforms
|
|
gptkbp:associatedWith
|
mitochondrial disorders
|
|
gptkbp:biologicalProcess
|
GO:0003968 (RNA-directed RNA polymerase activity)
RNA polymerase activity
GO:0006366 (transcription from mitochondrial promoter)
|
|
gptkbp:catalyzes
|
synthesis of RNA from mitochondrial DNA template
|
|
gptkbp:cellularComponent
|
mitochondrial matrix
GO:0005739 (mitochondrion)
|
|
gptkbp:conserved_domain
|
RNA_pol
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:encodedBy
|
POLRMT gene
|
|
gptkbp:Entrez_Gene_ID
|
5442
ENSG00000119714
|
|
gptkbp:enzymeCommissionNumber
|
2.7.7.6
|
|
gptkbp:expressedIn
|
all human tissues
|
|
gptkbp:fullName
|
mitochondrial DNA-directed RNA polymerase
|
|
gptkbp:function
|
transcription of mitochondrial DNA
|
|
gptkbp:gene
|
gptkb:POLRMT
|
|
gptkbp:HGNC_ID
|
9176
|
|
gptkbp:homologous_to
|
T7 bacteriophage RNA polymerase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
POLRMT
|
|
gptkbp:inhibitedBy
|
2-C-methyladenosine
|
|
gptkbp:interactsWith
|
gptkb:TFB1M
gptkb:TFB2M
gptkb:TFAM
|
|
gptkbp:length
|
1230
|
|
gptkbp:locatedOnChromosome
|
chr19p13.3
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
139 kDa
|
|
gptkbp:mutationAssociatedWith
|
mitochondrial transcription disorders
|
|
gptkbp:OMIM
|
601778
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Polrmt
|
|
gptkbp:orthologInZebrafish
|
polrmt
|
|
gptkbp:PDB
|
6ERP
|
|
gptkbp:phosphorylates
|
Serine 948
|
|
gptkbp:RefSeq
|
NM_005035
|
|
gptkbp:requires
|
mitochondrial DNA maintenance
mitochondrial gene expression
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
single subunit
|
|
gptkbp:subcellularLocation
|
mitochondrial matrix
|
|
gptkbp:UniProtID
|
O00411
|
|
gptkbp:bfsParent
|
gptkb:TFAM
|
|
gptkbp:bfsLayer
|
6
|