Mitochondrial transcription factor A

URI: https://gptkb.org/entity/Mitochondrial_transcription_factor_A
GPTKB entity
Statements (47)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alternativeName gptkb:mtTFA
gptkb:TFAM
gptkbp:biologicalProcess DNA binding
transcription factor activity
gptkbp:cellularComponent mitochondrion
gptkbp:degradedBy by Lon protease
gptkbp:discoveredBy T. Larsson et al.
gptkbp:encodedBy TFAM gene
gptkbp:Entrez_Gene_ID 7019
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function mitochondrial DNA maintenance
regulation of mitochondrial DNA transcription
gptkbp:GO gptkb:GO:0005739
GO:0003690
https://www.w3.org/2000/01/rdf-schema#label Mitochondrial transcription factor A
gptkbp:interactsWith gptkb:POLRMT
gptkb:TFB1M
gptkb:TFB2M
gptkbp:involvedIn mitochondrial transcription initiation
mtDNA nucleoid formation
gptkbp:length 246 amino acids
gptkbp:locale mitochondrial matrix
gptkbp:locatedOnChromosome 10q21.1
gptkbp:mutationAssociatedWith mitochondrial diseases
gptkbp:OMIM 600438
gptkbp:organism gptkb:human
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
gptkbp:PDB 3TQ6
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:regulates mitochondrial DNA replication
mitochondrial gene expression
mitochondrial genome copy number
upregulated by PGC-1α
gptkbp:requires mitochondrial biogenesis
mtDNA packaging
gptkbp:significance linked to cancer
linked to aging
linked to neurodegenerative diseases
gptkbp:structure contains two HMG-box domains
gptkbp:UniProtID Q00059
gptkbp:bfsParent gptkb:TFAM
gptkbp:bfsLayer 6