|
gptkbp:instanceOf
|
gptkb:disease
neurodegenerative disease
|
|
gptkbp:affects
|
gptkb:spinal_cord
brain
motor neurons
|
|
gptkbp:alsoKnownAs
|
gptkb:Lou_Gehrig's_disease
|
|
gptkbp:averageSurvivalAfterDiagnosis
|
2 to 5 years
|
|
gptkbp:awarenessEvent
|
gptkb:ALS_Ice_Bucket_Challenge
|
|
gptkbp:awarenessMonth
|
May
|
|
gptkbp:casualties
|
true
|
|
gptkbp:cause
|
difficulty breathing
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
|
|
gptkbp:causedBy
|
C9orf72 mutation
FUS mutation
SOD1 mutation
TARDBP mutation
|
|
gptkbp:diagnosedBy
|
gptkb:EMG
neurological examination
MRI
nerve conduction study
|
|
gptkbp:firstDescribed
|
gptkb:Jean-Martin_Charcot
1869
|
|
gptkbp:frequency
|
2 per 100,000 people per year
|
|
gptkbp:fullName
|
gptkb:Amyotrophic_Lateral_Sclerosis
|
|
gptkbp:hasNoCure
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ALS
|
|
gptkbp:ICD-10_code
|
G12.2
|
|
gptkbp:inheritance
|
familial
sporadic
|
|
gptkbp:MeSH_ID
|
D000690
|
|
gptkbp:notablePatient
|
gptkb:Stephen_Hawking
gptkb:Steve_Gleason
gptkb:Lou_Gehrig
gptkb:Augie_Nieto
gptkb:O.J._Brigance
|
|
gptkbp:OMIM
|
105400
|
|
gptkbp:onset
|
usually after age 40
|
|
gptkbp:organization
|
gptkb:ALS_Association
gptkb:MND_Association
|
|
gptkbp:prevalence
|
rare
|
|
gptkbp:prognosis
|
poor
|
|
gptkbp:progression
|
progressive
|
|
gptkbp:relatedTo
|
motor neuron disease
primary lateral sclerosis
progressive muscular atrophy
|
|
gptkbp:riskFactor
|
age
family history
male sex
genetic mutations
|
|
gptkbp:symptom
|
paralysis
cramps
muscle twitching
spasticity
|
|
gptkbp:treatment
|
gptkb:edaravone
gptkb:riluzole
|
|
gptkbp:bfsParent
|
gptkb:Amyotrophic_lateral_sclerosis
gptkb:Sam_Shepard
|
|
gptkbp:bfsLayer
|
4
|