|
gptkbp:instanceOf
|
class of antibiotics
|
|
gptkbp:administeredBy
|
oral
topical
intravenous
|
|
gptkbp:alsoKnownAs
|
sulfa drugs
|
|
gptkbp:category
|
antibacterial
synthetic antimicrobial
|
|
gptkbp:cause
|
photosensitivity
crystalluria
kernicterus in neonates
|
|
gptkbp:chemicalFormula
|
contains sulfonamide group
|
|
gptkbp:combinationProduct
|
gptkb:co-trimoxazole
|
|
gptkbp:combines
|
trimethoprim
|
|
gptkbp:contraindication
|
gptkb:G6PD_deficiency
pregnancy
infants
|
|
gptkbp:discoveredBy
|
gptkb:Gerhard_Domagk
|
|
gptkbp:example
|
gptkb:sulfasalazine
sulfacetamide
sulfadiazine
sulfamethoxazole
sulfisoxazole
|
|
gptkbp:excretion
|
kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sulfonamides
|
|
gptkbp:introducedIn
|
1930s
|
|
gptkbp:listedOn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:mechanismOfAction
|
inhibit folic acid synthesis
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:notEffectiveAgainst
|
fungi
viruses
anaerobic bacteria
|
|
gptkbp:regulates
|
prescription
|
|
gptkbp:resistantTo
|
altered target enzyme
decreased drug uptake
increased PABA production
|
|
gptkbp:sideEffect
|
gptkb:Stevens-Johnson_syndrome
gptkb:anemia
rash
allergic reactions
|
|
gptkbp:spectrumOfActivity
|
broad spectrum
|
|
gptkbp:target
|
dihydropteroate synthase
|
|
gptkbp:usedFor
|
gptkb:pneumocystis_pneumonia
gptkb:toxoplasmosis
urinary tract infections
bacterial infections
nocardiosis
|
|
gptkbp:bfsParent
|
gptkb:Saccharin
|
|
gptkbp:bfsLayer
|
5
|