Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:alternativeName |
Specificity protein 1
TSFP1 Transcription factor Sp1 |
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
gptkb:cancer gptkb:diabetes |
| gptkbp:binds |
GC-rich motifs
|
| gptkbp:discoveredBy |
1983
|
| gptkbp:DNA_binding_domain |
zinc finger
|
| gptkbp:expressedIn |
many tissues
|
| gptkbp:function |
transcriptional activation
regulation of gene expression DNA binding |
| gptkbp:gene |
gptkb:SP1
|
| https://www.w3.org/2000/01/rdf-schema#label |
Sp1 protein
|
| gptkbp:interactsWith |
gptkb:CBP/p300
gptkb:TATA-binding_protein gptkb:HDAC1 gptkb:p53 |
| gptkbp:locatedOnChromosome |
12q13.1
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~81 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:PDB |
1SP1
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation sumoylation acetylation |
| gptkbp:regulates |
apoptosis
cell differentiation DNA repair metabolism angiogenesis cell growth oncogenes immune response cell cycle tumor suppressor genes cell adhesion inflammatory response housekeeping genes response to oxidative stress microRNAs telomerase activity extracellular matrix genes |
| gptkbp:UniProtID |
P08047
|
| gptkbp:bfsParent |
gptkb:SP1_gene
gptkb:KLF6_protein |
| gptkbp:bfsLayer |
8
|