Sodium taurocholate co-transporting polypeptide

URI: https://gptkb.org/entity/Sodium_taurocholate_co-transporting_polypeptide
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
ABC transporter
gptkbp:alternativeName gptkb:NTCP
gptkb:SLC10A1_protein
gptkbp:encodedBy gptkb:SLC10A1_gene
gptkbp:Entrez_Gene_ID 6554
gptkbp:foundIn liver
gptkbp:function bile acid uptake
gptkbp:HGNC_ID 11016
https://www.w3.org/2000/01/rdf-schema#label Sodium taurocholate co-transporting polypeptide
gptkbp:inhibitedBy gptkb:rifampicin
gptkb:myrcludex_B
gptkb:bosentan
cyclosporin A
gptkbp:locatedIn hepatocyte basolateral membrane
gptkbp:locatedOnChromosome 14q24.1
gptkbp:molecularWeight ~56 kDa
gptkbp:mutationAssociatedWith hypercholanemia
reduced bile acid uptake
gptkbp:OMIM 600214
gptkbp:requires enterohepatic circulation of bile acids
gptkbp:significance gptkb:Hepatitis_B_virus_receptor
gptkb:Hepatitis_D_virus_receptor
gptkbp:species gptkb:Homo_sapiens
gptkbp:transmembraneDomains 7
gptkbp:transportation gptkb:taurocholate
thyroid hormones
estrone sulfate
bile acids
conjugated bile salts
gptkbp:UniProtID gptkb:Q14973
gptkbp:bfsParent gptkb:NTCP
gptkbp:bfsLayer 6