|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:SLC10A1_protein
|
|
gptkbp:encodedBy
|
gptkb:SLC10A1_gene
|
|
gptkbp:Entrez_Gene_ID
|
6550
|
|
gptkbp:fullName
|
gptkb:Sodium_taurocholate_co-transporting_polypeptide
|
|
gptkbp:function
|
bile acid transporter
|
|
gptkbp:gene
|
gptkb:SLC10A1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NTCP
|
|
gptkbp:locatedOnChromosome
|
14q24.1
|
|
gptkbp:location
|
liver
hepatocyte plasma membrane
|
|
gptkbp:molecularWeight
|
~56 kDa
|
|
gptkbp:OMIM
|
600214
|
|
gptkbp:publicTransit
|
sodium-dependent
|
|
gptkbp:receptorFor
|
gptkb:Hepatitis_B_virus
gptkb:Hepatitis_D_virus
|
|
gptkbp:role
|
mediates uptake of bile acids from portal blood
|
|
gptkbp:significance
|
mutations cause NTCP deficiency
mutations cause hypercholanemia
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:target
|
gptkb:bulevirtide
gptkb:myrcludex_B
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:transportation
|
bile salts
conjugated bile acids
glycine-conjugated bile acids
taurine-conjugated bile acids
|
|
gptkbp:UniProtID
|
gptkb:Q14973
|
|
gptkbp:bfsParent
|
gptkb:I2P
|
|
gptkbp:bfsLayer
|
5
|