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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:SR_proteins
|
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gptkbp:associatedWith
|
gptkb:cancer
spinal muscular atrophy
myelodysplastic syndromes
|
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gptkbp:conservedIn
|
eukaryotes
|
|
gptkbp:contains
|
gptkb:RS_domain
RNA recognition motif (RRM)
|
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gptkbp:discoveredBy
|
gptkb:Adrian_Krainer
|
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gptkbp:firstDescribed
|
early 1990s
|
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gptkbp:fullName
|
Serine/arginine-rich splicing factor proteins
|
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gptkbp:function
|
mRNA stability
translation regulation
regulation of alternative splicing
mRNA export
|
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gptkbp:GO_term
|
GO:0003723 (RNA binding)
GO:0008380 (RNA splicing)
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|
https://www.w3.org/2000/01/rdf-schema#label
|
SRSF proteins
|
|
gptkbp:interactsWith
|
U1 snRNP
CLK kinases
SRPK1
U2AF
|
|
gptkbp:locale
|
gptkb:nucleus
nuclear speckles
|
|
gptkbp:locatedOnChromosome
|
varies by member
|
|
gptkbp:member
|
gptkb:SRSF2
gptkb:SRSF1
gptkb:SRSF10
gptkb:SRSF11
gptkb:SRSF12
gptkb:SRSF3
gptkb:SRSF6
gptkb:SRSF7
gptkb:SRSF9
SRSF4
SRSF5
|
|
gptkbp:molecularWeight
|
20-40 kDa
|
|
gptkbp:orthologIn
|
gptkb:human
gptkb:mouse
gptkb:Drosophila_melanogaster
gptkb:Arabidopsis_thaliana
|
|
gptkbp:phosphorylates
|
regulates activity
|
|
gptkbp:proteinFamily
|
SR protein family
|
|
gptkbp:regulates
|
histone modification
dephosphorylation
kinase-mediated phosphorylation
|
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gptkbp:relatedTo
|
gptkb:spliceosome
pre-mRNA splicing
|
|
gptkbp:bfsParent
|
gptkb:RRM_domain
|
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gptkbp:bfsLayer
|
7
|