|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:EC-SOD
Extracellular SOD
Superoxide dismutase 3
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:pneumonia
oxidative stress
|
|
gptkbp:bindingPartner
|
gptkb:heparan_sulfate_proteoglycans
|
|
gptkbp:clinicalMarker
|
oxidative stress biomarker
|
|
gptkbp:cofactor
|
copper
zinc
|
|
gptkbp:discoveredBy
|
1980s
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:encodedBy
|
SOD3 gene
|
|
gptkbp:Entrez_Gene_ID
|
6649
|
|
gptkbp:expressionRegulation
|
oxidative stress
inflammatory cytokines
|
|
gptkbp:family
|
gptkb:superoxide_dismutase_family
|
|
gptkbp:fullName
|
Extracellular superoxide dismutase
|
|
gptkbp:function
|
catalyzes dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD3 (EC-SOD)
|
|
gptkbp:locatedOnChromosome
|
4p15.3-p15.1 (human)
|
|
gptkbp:location
|
extracellular space
|
|
gptkbp:molecularWeight
|
~30 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased oxidative stress
vascular dysfunction
|
|
gptkbp:oligomerization
|
tetramer
|
|
gptkbp:OMIM
|
185490
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:PDB
|
gptkb:1PU0
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:product
|
hydrogen peroxide
oxygen
|
|
gptkbp:significance
|
antioxidant defense
|
|
gptkbp:structure
|
gptkb:protein
|
|
gptkbp:substrate
|
gptkb:superoxide_anion
|
|
gptkbp:therapeuticPotential
|
antioxidant therapy
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:plasma
gptkb:kidney
heart
blood vessels
|
|
gptkbp:UniProtID
|
P08294
|
|
gptkbp:bfsParent
|
gptkb:Cu,Zn-SOD
|
|
gptkbp:bfsLayer
|
7
|