|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Manganese_superoxide_dismutase
gptkb:MnSOD
|
|
gptkbp:associatedWith
|
gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
mitochondrial diseases
|
|
gptkbp:cofactor
|
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:encodedBy
|
gptkb:SOD2_gene
|
|
gptkbp:Enzyme_class
|
oxidoreductase
|
|
gptkbp:fullName
|
Superoxide dismutase [Mn], mitochondrial
|
|
gptkbp:function
|
catalyzes dismutation of superoxide radicals to hydrogen peroxide and oxygen
|
|
gptkbp:gene
|
gptkb:SOD2
|
|
gptkbp:GO_term
|
gptkb:GO:0004784
gptkb:GO:0005739
GO:0006979
|
|
gptkbp:highestExpression
|
gptkb:kidney
brain
heart
liver
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD2 (human)
|
|
gptkbp:inhibitedBy
|
gptkb:diethyldithiocarbamate
hydroxylamine
|
|
gptkbp:locatedOnChromosome
|
6q25.3
|
|
gptkbp:location
|
mitochondrion
|
|
gptkbp:molecularWeight
|
24 kDa (monomer)
|
|
gptkbp:mutationAssociatedWith
|
mitochondrial dysfunction
increased oxidative stress
|
|
gptkbp:OMIM
|
147460
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila SOD2
mouse SOD2
yeast SOD2
|
|
gptkbp:pathway
|
oxidative stress response
cellular response to superoxide
ROS detoxification
|
|
gptkbp:PDB
|
gptkb:1LUV
gptkb:1N0J
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:RefSeq
|
NP_000627.2
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P04179
|
|
gptkbp:bfsParent
|
gptkb:Sod2
|
|
gptkbp:bfsLayer
|
7
|