Amyotrophic lateral sclerosis

URI: https://gptkb.org/entity/Amyotrophic_lateral_sclerosis
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:disease
gptkbp:affects lower motor neurons
motor neurons
upper motor neurons
gptkbp:alsoKnownAs gptkb:Lou_Gehrig's_disease
gptkb:ALS
gptkbp:averageAgeOfOnset 55
gptkbp:averageSurvivalAfterDiagnosis 2 to 5 years
gptkbp:casualties yes
gptkbp:category neurodegenerative disease
motor neuron disease
gptkbp:cause difficulty breathing
unknown
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
gptkbp:diagnosedBy MRI
clinical examination
electromyography
nerve conduction study
gptkbp:firstDescribed 1869
gptkbp:hereditary sometimes
https://www.w3.org/2000/01/rdf-schema#label Amyotrophic lateral sclerosis
gptkbp:ICD-10_code G12.2
gptkbp:incidence 2 per 100,000 per year
gptkbp:MeSH_ID D000690
gptkbp:mutationAssociatedWith gptkb:C9orf72
gptkb:FUS
gptkb:SOD1
gptkb:TARDBP
gptkbp:namedAfter gptkb:Jean-Martin_Charcot
gptkbp:notablePatient gptkb:Stephen_Hawking
gptkb:Lou_Gehrig
gptkbp:onset adult
gptkbp:prognosis poor
gptkbp:progression progressive
gptkbp:symptom weight loss
cramps
emotional lability
muscle twitching
spasticity
gptkbp:treatment gptkb:edaravone
gptkb:riluzole
supportive care
physical therapy
speech therapy
ventilation support
gptkbp:bfsParent gptkb:Henry_A._Wallace
gptkbp:bfsLayer 3