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gptkbp:instance_of
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gptkb:neurodegenerative_diseases
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gptkbp:advocacy
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gptkb:ALS_Therapy_Development_Institute
gptkb:ALS_Association
gptkb:MDA_(Muscular_Dystrophy_Association)
gptkb:ALS_Society_of_Canada
gptkb:Motor_Neurone_Disease_Association_(UK)
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|
gptkbp:affects
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motor neurons
both genders
|
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gptkbp:associated_with
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gptkb:frontotemporal_dementia
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gptkbp:cause
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death of motor neurons
|
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gptkbp:caused_by
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environmental factors
genetic mutations
|
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gptkbp:clinical_trial
|
ongoing
completed
|
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gptkbp:color
|
purple
|
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gptkbp:condition
|
gptkb:frontotemporal_dementia
gptkb:depression
pain
cognitive changes
spasticity
|
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gptkbp:diagnosis
|
clinical examination
varies by individual
electromyography
|
|
gptkbp:famous_person
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gptkb:Terry_Fox
gptkb:Jason_Becker
gptkb:A._J._Styles
gptkb:Pat_Quinn
gptkb:Steve_Gleason
gptkb:Stephen_Hawking
gptkb:Morrissey
gptkb:Lou_Gehrig
gptkb:David_Niven
Glen Mc Mahon
Tommy Mc Hugh
|
|
gptkbp:first_described_by
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gptkb:Jean-Martin_Charcot
|
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gptkbp:genetic_studies
|
C9orf72 mutations
SOD1 mutations
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Amyotrophic lateral sclerosis
|
|
gptkbp:is_involved_in
|
gptkb:ALS_Society
gptkb:ALS_Association
gptkb:MDA_(Muscular_Dystrophy_Association)
|
|
gptkbp:known_as
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gptkb:Lou_Gehrig's_disease
|
|
gptkbp:lifespan
|
3 to 5 years after diagnosis
|
|
gptkbp:player_development
|
varies among individuals
|
|
gptkbp:premiered_on
|
typically between ages 40 and 70
typically between 40 and 70
|
|
gptkbp:prevalence
|
2 per 100,000 people
|
|
gptkbp:public_awareness
|
gptkb:ALS_Awareness_Month
gptkb:ALS_Ice_Bucket_Challenge
|
|
gptkbp:research
|
ongoing clinical trials
|
|
gptkbp:research_focus
|
gptkb:gene_therapy
gptkb:immunotherapy
biomarkers
neuroprotective agents
stem cell therapy
|
|
gptkbp:symptoms
|
fatigue
respiratory failure
difficulty speaking
muscle weakness
difficulty swallowing
muscle atrophy
cramps
cognitive changes
emotional lability
twitching
|
|
gptkbp:treatment
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gptkb:riluzole
gptkb:edaravone
supportive care
|
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gptkbp:bfsParent
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gptkb:Lou_Gehrig
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gptkbp:bfsLayer
|
4
|