superoxide dismutase [Cu-Zn]
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:SOD1
gptkb:Cu,Zn-superoxide_dismutase |
| gptkbp:catalyzes |
dismutation of superoxide radicals
|
| gptkbp:cofactor |
copper
zinc |
| gptkbp:discoveredBy |
gptkb:Irwin_Fridovich
|
| gptkbp:discoveredIn |
1969
|
| gptkbp:EC_number |
1.15.1.1
|
| gptkbp:foundIn |
gptkb:cytoplasm
eukaryotes some prokaryotes |
| gptkbp:function |
protects cells from oxidative stress
|
| gptkbp:gene |
gptkb:SOD1
|
| https://www.w3.org/2000/01/rdf-schema#label |
superoxide dismutase [Cu-Zn]
|
| gptkbp:locatedOnChromosome |
gptkb:human_chromosome_21q22.11
|
| gptkbp:molecularWeight |
~32 kDa (dimer)
|
| gptkbp:mutationAssociatedWith |
amyotrophic lateral sclerosis
|
| gptkbp:OMIM |
147450
|
| gptkbp:PDB |
gptkb:1HL5
|
| gptkbp:product |
hydrogen peroxide
oxygen |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
gptkb:superoxide_anion
|
| gptkbp:UniProtID |
gptkb:P00441
|
| gptkbp:bfsParent |
gptkb:SOD1
|
| gptkbp:bfsLayer |
5
|