Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
JAB (Janus kinase binding protein)
SSI (STAT-induced STAT inhibitor) SSI family proteins |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases metabolic disorders |
| gptkbp:discoveredBy |
Douglas Hilton
|
| gptkbp:domain |
gptkb:SOCS_box
SH2 domain |
| gptkbp:firstDescribed |
1997
|
| gptkbp:fullName |
Suppressor of Cytokine Signaling family proteins
|
| gptkbp:function |
negative regulation of cytokine signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
SOCS family proteins
|
| gptkbp:inducedBy |
cytokines
growth factors |
| gptkbp:locatedOnChromosome |
various chromosomes
|
| gptkbp:mechanismOfAction |
inhibition of JAK-STAT pathway
|
| gptkbp:member |
gptkb:SOCS1
gptkb:SOCS2 gptkb:SOCS3 gptkb:SOCS4 gptkb:SOCS5 gptkb:SOCS6 gptkb:SOCS7 gptkb:CIS_(Cytokine_Inducible_SH2-containing_protein) |
| gptkbp:orthologIn |
gptkb:fish
birds mammals |
| gptkbp:regulates |
cell growth
inflammation immune response hematopoiesis |
| gptkbp:bfsParent |
gptkb:SOCS_box
|
| gptkbp:bfsLayer |
7
|