Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
SMAD specific E3 ubiquitin protein ligase 2
SMAD ubiquitination regulatory factor 2 |
| gptkbp:associatedWith |
gptkb:cancer
fibrosis |
| gptkbp:biologicalProcess |
gptkb:TGF-beta_signaling_pathway
protein ubiquitination ubiquitin-protein transferase activity |
| gptkbp:cellularComponent |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:domain |
gptkb:WW_domain
gptkb:HECT_domain C2 domain |
| gptkbp:encodedBy |
SMURF2 gene
|
| gptkbp:function |
gptkb:E3_ubiquitin-protein_ligase
|
| gptkbp:interactsWith |
gptkb:SMURF1_protein
SMAD2 protein SMAD7 protein RNF20 protein |
| gptkbp:length |
748 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:17q23.3
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:regulates |
cell proliferation
cellular senescence cell cycle TGF-beta receptor degradation |
| gptkbp:UniProtID |
Q9HAU4
|
| gptkbp:bfsParent |
gptkb:WW_domain
|
| gptkbp:bfsLayer |
7
|
| http://www.w3.org/2000/01/rdf-schema#label |
SMURF2 protein
|