Signal-regulatory protein alpha
GPTKB entity
Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:BIT
gptkb:P84 gptkb:SIRPĪ± SHPS-1 |
| gptkbp:binds |
gptkb:CD47
|
| gptkbp:biologicalProcess |
immunoglobulin superfamily member
|
| gptkbp:domain |
immunoglobulin-like domain
|
| gptkbp:expressedIn |
neurons
dendritic cells macrophages myeloid cells |
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
cell surface receptor
negative regulator of receptor tyrosine kinase-coupled signaling processes |
| gptkbp:gene |
gptkb:SIRPA
|
| gptkbp:HGNC_ID |
gptkb:HGNC:9666
|
| https://www.w3.org/2000/01/rdf-schema#label |
Signal-regulatory protein alpha
|
| gptkbp:interactsWith |
protein tyrosine phosphatases SHP-1 and SHP-2
|
| gptkbp:involves |
immune response
phagocytosis inhibition |
| gptkbp:locatedOnChromosome |
gptkb:20p13
|
| gptkbp:location |
gptkb:plasma_membrane
|
| gptkbp:OMIM |
601877
|
| gptkbp:PDB |
2JJS
|
| gptkbp:role |
neurodegenerative diseases
autoimmune diseases cancer immune evasion |
| gptkbp:UniProtID |
gptkb:P78324
|
| gptkbp:bfsParent |
gptkb:SIRPA
|
| gptkbp:bfsLayer |
7
|