Signal-regulatory protein alpha

URI: https://gptkb.org/entity/Signal-regulatory_protein_alpha
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:BIT
gptkb:P84
gptkb:SIRPĪ±
SHPS-1
gptkbp:binds gptkb:CD47
gptkbp:biologicalProcess immunoglobulin superfamily member
gptkbp:domain immunoglobulin-like domain
gptkbp:expressedIn gptkb:neurons
dendritic cells
macrophages
myeloid cells
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function gptkb:cell_surface_receptor
negative regulator of receptor tyrosine kinase-coupled signaling processes
gptkbp:gene gptkb:SIRPA
gptkbp:HGNC_ID gptkb:HGNC:9666
gptkbp:interactsWith protein tyrosine phosphatases SHP-1 and SHP-2
gptkbp:involves gptkb:immune_response
phagocytosis inhibition
gptkbp:locatedOnChromosome gptkb:20p13
gptkbp:location gptkb:plasma_membrane
gptkbp:OMIM 601877
gptkbp:PDB 2JJS
gptkbp:role neurodegenerative diseases
autoimmune diseases
cancer immune evasion
gptkbp:UniProtID gptkb:P78324
gptkbp:bfsParent gptkb:SIRPA
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Signal-regulatory protein alpha