Statements (176)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
serine protease inhibitor family
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:cancer gptkb:cardiovascular_disease gptkb:liver_disease gptkb:pneumonia gptkb:diabetes gptkb:hereditary_hemorrhagic_telangiectasia gptkb:alpha-1_antitrypsin_deficiency stroke obesity emphysema neurodegenerative diseases sepsis autoimmune diseases inflammatory diseases thrombosis infertility immune deficiency |
| gptkbp:database |
InterPro: IPR023795
MEROPS: I4 PROSITE: PS00284 Pfam: PF00079 SCOP: 1ova |
| gptkbp:foundIn |
gptkb:Bacteria
animals fungi plants |
| gptkbp:function |
inhibits serine proteases
|
| https://www.w3.org/2000/01/rdf-schema#label |
SERPIN family
|
| gptkbp:member |
gptkb:SERPINB5
gptkb:SERPINB2 gptkb:SERPINE1 gptkb:SERPINA1 gptkb:SERPINA3 gptkb:SERPINA5 gptkb:SERPINC1 SERPINA8 SERPINA10 SERPINF1 SERPING1 SERPINA100 SERPINA12 SERPINA13 SERPINA14 SERPINA15 SERPINA16 SERPINA18 SERPINA20 SERPINA21 SERPINA22 SERPINA23 SERPINA24 SERPINA25 SERPINA26 SERPINA27 SERPINA28 SERPINA29 SERPINA30 SERPINA31 SERPINA32 SERPINA33 SERPINA34 SERPINA35 SERPINA36 SERPINA37 SERPINA38 SERPINA39 SERPINA40 SERPINA41 SERPINA42 SERPINA43 SERPINA44 SERPINA45 SERPINA46 SERPINA47 SERPINA48 SERPINA49 SERPINA50 SERPINA51 SERPINA52 SERPINA53 SERPINA54 SERPINA55 SERPINA56 SERPINA57 SERPINA58 SERPINA59 SERPINA6 SERPINA60 SERPINA61 SERPINA62 SERPINA63 SERPINA64 SERPINA65 SERPINA66 SERPINA67 SERPINA68 SERPINA69 SERPINA7 SERPINA70 SERPINA71 SERPINA72 SERPINA73 SERPINA74 SERPINA75 SERPINA76 SERPINA77 SERPINA78 SERPINA79 SERPINA80 SERPINA81 SERPINA82 SERPINA83 SERPINA84 SERPINA85 SERPINA86 SERPINA87 SERPINA88 SERPINA89 SERPINA9 SERPINA90 SERPINA91 SERPINA92 SERPINA93 SERPINA94 SERPINA95 SERPINA96 SERPINA97 SERPINA98 SERPINA99 SERPINB1 SERPINB10 SERPINB11 SERPINB12 SERPINB3 SERPINB4 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPIND1 |
| gptkbp:proteinFamily |
SERPIN
|
| gptkbp:role |
gptkb:disease
apoptosis cell differentiation cell proliferation development aging fertility wound healing metabolism angiogenesis cell migration cell signaling protein folding inflammation immune response protein quality control blood coagulation tumor suppression oxidative stress response tissue homeostasis cell death neuroprotection antiviral defense extracellular matrix remodeling hormone transport antibacterial defense antiparasitic defense |
| gptkbp:structure |
conserved serpin fold
|
| gptkbp:superfamily |
gptkb:serine_protease_inhibitors
|
| gptkbp:bfsParent |
gptkb:Serpina
|
| gptkbp:bfsLayer |
7
|