|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:EDG1
Endothelial differentiation, G-protein-coupled receptor 1
|
|
gptkbp:associatedWith
|
multiple sclerosis
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
angiogenesis
cell migration
immune response
G-protein coupled receptor activity
|
|
gptkbp:encodedBy
|
S1PR1 gene
|
|
gptkbp:Entrez_Gene_ID
|
1901
ENSG00000170989
|
|
gptkbp:expressedIn
|
gptkb:cancer
brain
heart
endothelial cells
lymphocytes
|
|
gptkbp:family
|
G-protein coupled receptor family
|
|
gptkbp:fullName
|
Sphingosine-1-phosphate receptor 1
|
|
gptkbp:function
|
regulates immune cell trafficking
involved in vascular maturation
mediates cell migration
G-protein coupled receptor for sphingosine-1-phosphate
regulates endothelial cell function
|
|
gptkbp:HGNC_ID
|
HGNC:3165
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
S1PR1
|
|
gptkbp:length
|
382 amino acids
|
|
gptkbp:ligand
|
gptkb:sphingosine-1-phosphate
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p22
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:mutationAssociatedWith
|
impaired lymphocyte trafficking
vascular leakage
|
|
gptkbp:OMIM
|
601974
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
Immune system pathway
Sphingolipid signaling pathway
Vascular development pathway
|
|
gptkbp:PDB
|
3V2Y
7VIE
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:subfamily
|
gptkb:EDG_family
|
|
gptkbp:target
|
gptkb:ozanimod
gptkb:siponimod
gptkb:fingolimod
|
|
gptkbp:UniProtID
|
gptkb:P21453
|
|
gptkbp:bfsParent
|
gptkb:sphingosine-1-phosphate_receptor_1
|
|
gptkbp:bfsLayer
|
7
|