fingolimod

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:drug
immunotherapy
gptkbp:approvalYear 2010
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode gptkb:L04AA27
gptkbp:brand gptkb:Gilenya
gptkbp:CASNumber gptkb:162359-55-9
gptkbp:chemicalClass sphingosine analog
gptkbp:contraindication severe liver impairment
recent myocardial infarction
AV block
gptkbp:developer gptkb:Novartis
gptkbp:discoveredBy gptkb:Yoshitomi_Pharmaceuticals
gptkbp:dose 0.5 mg daily
gptkbp:eliminationHalfLife 6-9 days
gptkbp:excretion urine
feces
gptkbp:form capsule
gptkbp:genericName yes
gptkbp:hasMolecularFormula C19H33NO2
https://www.w3.org/2000/01/rdf-schema#label fingolimod
gptkbp:indication relapsing-remitting multiple sclerosis
gptkbp:KEGGID D08967
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction sphingosine-1-phosphate receptor modulator
gptkbp:MeSH_ID C526747
gptkbp:metabolism liver
gptkbp:molecularWeight 307.47 g/mol
gptkbp:monitors heart rate
liver function
ophthalmologic exam
gptkbp:notRecommendedFor gptkb:secondary_progressive_multiple_sclerosis
primary progressive multiple sclerosis
gptkbp:origin synthetic
gptkbp:patentExpired 2019 (US)
gptkbp:pregnancyCategory gptkb:X_(US)
gptkbp:pregnancyWarning teratogenic
gptkbp:PubChem_CID gptkb:DB08868
gptkb:CHEMBL1176
107970
gptkbp:riskFactor gptkb:cancer
gptkb:progressive_multifocal_leukoencephalopathy
infections
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:lymphopenia
gptkb:macular_edema
bradycardia
liver enzyme elevation
gptkbp:UNII G9200DO99Z
gptkbp:usedFor multiple sclerosis
gptkbp:bfsParent gptkb:Gilenya
gptkbp:bfsLayer 5