Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abnormalExpressionAssociatedWith |
gptkb:Alzheimer's_disease
gptkb:cancer gptkb:cardiovascular_disease autoimmune disease |
| gptkbp:binds |
calcium ions
copper ions target proteins zinc ions |
| gptkbp:discoveredBy |
Brocklehurst et al.
|
| gptkbp:discoveredIn |
1965
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
calcium binding
regulation of protein phosphorylation involvement in apoptosis involvement in cell cycle progression involvement in cell migration involvement in cytoskeleton dynamics involvement in differentiation involvement in inflammation regulation of transcription factors |
| https://www.w3.org/2000/01/rdf-schema#label |
S100 protein
|
| gptkbp:locatedOnChromosome |
chromosome 1q21 (many members)
|
| gptkbp:member |
gptkb:S100G
gptkb:S100B gptkb:S100A1 gptkb:S100A10 gptkb:S100A11 gptkb:S100A12 gptkb:S100A2 gptkb:S100A4 gptkb:S100A6 gptkb:S100A8 gptkb:S100A9 gptkb:S100P gptkb:S100A13 gptkb:S100A14 gptkb:S100A15 gptkb:S100A16 gptkb:S100A3 gptkb:S100A5 gptkb:S100A7 gptkb:S100Z |
| gptkbp:numberOfMembers |
at least 21
|
| gptkbp:regulates |
cell differentiation
cell survival cell growth cell motility inflammatory response enzyme activity |
| gptkbp:significance |
biomarker for certain cancers
biomarker for brain injury biomarker for heart failure biomarker for inflammatory diseases biomarker for melanoma |
| gptkbp:structure |
EF-hand calcium-binding motif
|
| gptkbp:subcellularLocation |
gptkb:nucleus
gptkb:cytoplasm extracellular space |
| gptkbp:bfsParent |
gptkb:Schwann_cell
|
| gptkbp:bfsLayer |
6
|