methionine adenosyltransferase
GPTKB entity
Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
AdoMet synthetase
SAM synthetase |
| gptkbp:associatedWith |
hypermethioninemia
|
| gptkbp:biologicalProcess |
S-adenosylmethionine biosynthetic process
methionine adenosyltransferase activity |
| gptkbp:CASNumber |
9029-94-5
|
| gptkbp:catalyzes |
S-adenosylmethionine synthesis
|
| gptkbp:cofactor |
K+
Mg2+ |
| gptkbp:EC_number |
2.5.1.6
|
| gptkbp:expressedIn |
gptkb:kidney
brain liver all tissues (MAT2A, MAT2B) |
| gptkbp:firstDescribed |
1959
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:gene |
MAT1A
MAT2A MAT2B |
| https://www.w3.org/2000/01/rdf-schema#label |
methionine adenosyltransferase
|
| gptkbp:involves |
methionine metabolism
S-adenosylmethionine biosynthesis |
| gptkbp:OMIM_ID_(MAT1A) |
250850
|
| gptkbp:OMIM_ID_(MAT2A) |
601468
|
| gptkbp:OMIM_ID_(MAT2B) |
601468
|
| gptkbp:PDB |
1P7L
2OBV 2P02 |
| gptkbp:product |
gptkb:S-adenosylmethionine
phosphate pyrophosphate |
| gptkbp:proteinFamily |
transferase
|
| gptkbp:regulates |
feedback inhibition by S-adenosylmethionine
regulated by ATP levels regulated by methionine availability |
| gptkbp:requires |
transsulfuration pathway
polyamine biosynthesis methylation reactions |
| gptkbp:structure |
homodimer (in some species)
homotetramer (in some species) |
| gptkbp:substrate |
gptkb:ATP
L-methionine |
| gptkbp:UniProt_ID_(human_MAT1A) |
P31153
|
| gptkbp:UniProt_ID_(human_MAT2A) |
P31154
|
| gptkbp:UniProt_ID_(human_MAT2B) |
Q9NZD8
|
| gptkbp:bfsParent |
gptkb:S-adenosyl_methionine
gptkb:S-adenosylmethionine gptkb:S-Adenosyl_methionine_(SAMe) |
| gptkbp:bfsLayer |
7
|