|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
sympathetic nervous system
low blood pressure
low sodium concentration
|
|
gptkbp:alsoKnownAs
|
gptkb:angiotensinogenase
|
|
gptkbp:associatedWith
|
congestive heart failure
hypertension
hypotension
primary hyperaldosteronism
renal artery stenosis
|
|
gptkbp:CASNumber
|
9001-22-3
|
|
gptkbp:category
|
gptkb:protease
peptidase
blood pressure regulation protein
|
|
gptkbp:discoveredBy
|
gptkb:Per_Bergman
gptkb:Robert_Tigerstedt
|
|
gptkbp:discoveredIn
|
1898
|
|
gptkbp:EC_number
|
3.4.23.15
|
|
gptkbp:encodedBy
|
gptkb:REN_gene
|
|
gptkbp:function
|
regulates blood pressure
catalyzes conversion of angiotensinogen to angiotensin I
regulates electrolyte balance
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Renin
|
|
gptkbp:inhibitedBy
|
gptkb:angiotensin_II
high blood pressure
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q32
|
|
gptkbp:molecularWeight
|
~37 kDa
|
|
gptkbp:partOf
|
gptkb:renin-angiotensin_system
|
|
gptkbp:pH_optimum
|
5.5-6.0
|
|
gptkbp:producedBy
|
gptkb:kidney
gptkb:juxtaglomerular_cells
|
|
gptkbp:product
|
gptkb:angiotensin_I
|
|
gptkbp:significance
|
measured in diagnosis of hypertension
measured in diagnosis of primary aldosteronism
|
|
gptkbp:species
|
gptkb:human
mammals
|
|
gptkbp:structure
|
gptkb:aspartic_protease
|
|
gptkbp:substrate
|
gptkb:angiotensinogen
|
|
gptkbp:UniProtID
|
gptkb:P00797
|
|
gptkbp:bfsParent
|
gptkb:Kidneys
|
|
gptkbp:bfsLayer
|
6
|