|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeSiteResidue
|
Serine 365
|
|
gptkbp:alternativeName
|
gptkb:Christmas_factor
Plasma thromboplastin component
|
|
gptkbp:associatedWith
|
gptkb:Hemophilia_B
|
|
gptkbp:catalyzes
|
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor X to form factor Xa
|
|
gptkbp:chain
|
29-461
|
|
gptkbp:disulfideBond
|
Between Cys191 and Cys220
|
|
gptkbp:Entrez_Gene_ID
|
2158
ENSG00000101981
|
|
gptkbp:enzymeClassification
|
EC 3.4.21.22
|
|
gptkbp:expressedIn
|
Expressed in liver and plasma
|
|
gptkbp:function
|
Essential component of the blood coagulation cascade
|
|
gptkbp:gene
|
gptkb:F9
|
|
gptkbp:glycosylation
|
Asn157
Asn167
|
|
gptkbp:hasIsoform
|
2
|
|
gptkbp:HGNC_ID
|
HGNC:3545
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P00797
|
|
gptkbp:KEGGID
|
hsa:2158
|
|
gptkbp:lastAnnotationUpdate
|
2022-02-23
|
|
gptkbp:latestReleaseVersion
|
2001-11-01
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:location
|
Xq27.1-q27.2
|
|
gptkbp:molecularWeight
|
51599 Da
|
|
gptkbp:mutationAssociatedWith
|
Deficiency causes Hemophilia B
|
|
gptkbp:OMIM
|
306900
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Cow F9
Mouse F9
Rat F9
|
|
gptkbp:pathway
|
Blood coagulation
|
|
gptkbp:PDB
|
1PFX
1RFN
2WPH
|
|
gptkbp:pharmaceuticalUse
|
Used in treatment of Hemophilia B
|
|
gptkbp:postTranslationalModification
|
Disulfide bond
Glycosylation
Gamma-carboxylation
|
|
gptkbp:protein_existence
|
Evidence at protein level
|
|
gptkbp:recommendation
|
Coagulation factor IX
|
|
gptkbp:RefSeq
|
NP_000124.1
|
|
gptkbp:sequence
|
461
|
|
gptkbp:sequenceStatus
|
Reviewed
|
|
gptkbp:signalPeptide
|
1-28
|
|
gptkbp:structure
|
Contains 1 EGF-like domain
Contains 1 Gla domain
Contains 1 peptidase S1 domain
|
|
gptkbp:subcellularLocation
|
Secreted
|
|
gptkbp:tissue_specificity
|
Liver
|
|
gptkbp:UniProtID
|
gptkb:P00797
|
|
gptkbp:bfsParent
|
gptkb:renin
|
|
gptkbp:bfsLayer
|
6
|