Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
guanine nucleotide exchange factors (GEFs)
|
| gptkbp:activeState |
GTP-bound
|
| gptkbp:binds |
gptkb:GDP
gptkb:GTP |
| gptkbp:contains |
gptkb:GTP-binding_domain
|
| gptkbp:decommissioned |
GTPase-activating proteins (GAPs)
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:distinctFrom |
Ras proteins by effector interactions
|
| gptkbp:encodedBy |
RAP genes
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
small molecule
|
| gptkbp:gene |
gptkb:RAP1A
gptkb:RAP1B gptkb:RAP2A gptkb:RAP2B gptkb:RAP2C |
| https://www.w3.org/2000/01/rdf-schema#label |
Rap proteins
|
| gptkbp:inactiveState |
GDP-bound
|
| gptkbp:include |
gptkb:Rap1
gptkb:Rap2 |
| gptkbp:involvedIn |
signal transduction
vesicle trafficking neuronal development immune cell function cytoskeletal reorganization |
| gptkbp:memberOf |
gptkb:Ras_superfamily
|
| gptkbp:orthologIn |
gptkb:Ras_proteins
|
| gptkbp:regulates |
gptkb:MAPK_signaling_pathway
gptkb:synaptic_plasticity gptkb:cAMP_signaling_pathway cell differentiation cell proliferation cell migration cell polarity cell adhesion cell junction formation endocytosis exocytosis axon guidance cadherin-mediated cell adhesion cell-cell junctions cellular response to cAMP endothelial barrier function integrin-mediated signaling leukocyte function platelet activation |
| gptkbp:structure |
gptkb:G-domain
|
| gptkbp:subfamily |
Ras-related proteins
|
| gptkbp:bfsParent |
gptkb:Ras_domain
|
| gptkbp:bfsLayer |
6
|