|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:activeState
|
GTP-bound
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:contains
|
gptkb:GTP-binding_domain
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:distinctFrom
|
Ras proteins by effector interactions
|
|
gptkbp:encodedBy
|
RAP genes
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
gptkb:small_molecule
|
|
gptkbp:gene
|
gptkb:RAP1A
gptkb:RAP1B
gptkb:RAP2A
gptkb:RAP2B
gptkb:RAP2C
|
|
gptkbp:inactiveState
|
GDP-bound
|
|
gptkbp:include
|
gptkb:Rap1
gptkb:Rap2
|
|
gptkbp:involvedIn
|
signal transduction
vesicle trafficking
neuronal development
immune cell function
cytoskeletal reorganization
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:orthologIn
|
gptkb:Ras_proteins
|
|
gptkbp:regulates
|
gptkb:MAPK_signaling_pathway
gptkb:synaptic_plasticity
gptkb:cAMP_signaling_pathway
cell differentiation
cell proliferation
cell migration
cell polarity
cell adhesion
cell junction formation
endocytosis
exocytosis
axon guidance
cadherin-mediated cell adhesion
cell-cell junctions
cellular response to cAMP
endothelial barrier function
integrin-mediated signaling
leukocyte function
platelet activation
|
|
gptkbp:structure
|
gptkb:G-domain
|
|
gptkbp:subfamily
|
Ras-related proteins
|
|
gptkbp:bfsParent
|
gptkb:Ras_domain
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rap proteins
|