|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
NOT
NURR1
TINUR
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
schizophrenia
inflammatory diseases
|
|
gptkbp:discoveredBy
|
K. Zetterström et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
Nuclear receptor subfamily 4 group A member 2
|
|
gptkbp:Entrez_Gene_ID
|
4929
ENSG00000110092
|
|
gptkbp:expressedIn
|
brain
dopaminergic neurons
|
|
gptkbp:function
|
gptkb:transcription_factor
regulation of dopaminergic neuron development
|
|
gptkbp:geneType
|
protein coding
|
|
gptkbp:has3PrimeUTR
|
yes
|
|
gptkbp:has5PrimeUTR
|
yes
|
|
gptkbp:hasMouseModel
|
Nurr1 knockout mouse
|
|
gptkbp:hasPromoter
|
TATA-less promoter
|
|
gptkbp:hasPseudogene
|
NR4A2P1
|
|
gptkbp:hasTranscriptVariant
|
NR4A2-201
NR4A2-202
|
|
gptkbp:HGNC_ID
|
7981
|
|
gptkbp:interactsWith
|
gptkb:RXR_(Retinoid_X_Receptor)
coactivators
|
|
gptkbp:length
|
598 amino acids (canonical isoform)
|
|
gptkbp:locatedOnChromosome
|
chromosome 2
|
|
gptkbp:molecularWeight
|
65 kDa (approximate)
|
|
gptkbp:mutationAssociatedWith
|
motor deficits
dopaminergic neuron loss
|
|
gptkbp:OMIM
|
601828
|
|
gptkbp:orthologInMouse
|
Nr4a2
|
|
gptkbp:proteinFamily
|
DNA-binding domain
ligand-binding domain
nuclear receptor family
|
|
gptkbp:regulates
|
gptkb:immune_response
gptkb:tyrosine_hydroxylase_gene
apoptosis
cell survival
neuronal differentiation
inflammatory response
dopamine biosynthesis
acts as a transcriptional activator
dopamine transporter gene
|
|
gptkbp:significance
|
mutations linked to familial Parkinson's disease
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
pharmacological research
|
|
gptkbp:UniProtID
|
P43354
|
|
gptkbp:bfsParent
|
gptkb:NR4
gptkb:Nuclear_receptor_superfamily
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NR4A2
|