Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
NOT
NURR1 TINUR |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:Parkinson's_disease
schizophrenia inflammatory diseases |
| gptkbp:discoveredBy |
K. Zetterström et al.
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:encodes |
Nuclear receptor subfamily 4 group A member 2
|
| gptkbp:Entrez_Gene_ID |
4929
ENSG00000110092 |
| gptkbp:expressedIn |
brain
dopaminergic neurons |
| gptkbp:function |
transcription factor
regulation of dopaminergic neuron development |
| gptkbp:geneType |
protein coding
|
| gptkbp:has3PrimeUTR |
yes
|
| gptkbp:has5PrimeUTR |
yes
|
| gptkbp:hasMouseModel |
Nurr1 knockout mouse
|
| gptkbp:hasPromoter |
TATA-less promoter
|
| gptkbp:hasPseudogene |
NR4A2P1
|
| gptkbp:hasTranscriptVariant |
NR4A2-201
NR4A2-202 |
| gptkbp:HGNC_ID |
7981
|
| https://www.w3.org/2000/01/rdf-schema#label |
NR4A2
|
| gptkbp:interactsWith |
gptkb:RXR_(Retinoid_X_Receptor)
coactivators |
| gptkbp:length |
598 amino acids (canonical isoform)
|
| gptkbp:locatedOnChromosome |
chromosome 2
|
| gptkbp:molecularWeight |
65 kDa (approximate)
|
| gptkbp:mutationAssociatedWith |
motor deficits
dopaminergic neuron loss |
| gptkbp:OMIM |
601828
|
| gptkbp:orthologInMouse |
Nr4a2
|
| gptkbp:proteinFamily |
DNA-binding domain
ligand-binding domain nuclear receptor family |
| gptkbp:regulates |
gptkb:tyrosine_hydroxylase_gene
apoptosis cell survival immune response neuronal differentiation inflammatory response dopamine biosynthesis acts as a transcriptional activator dopamine transporter gene |
| gptkbp:significance |
mutations linked to familial Parkinson's disease
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:subcellularLocation |
gptkb:nucleus
|
| gptkbp:target |
pharmacological research
|
| gptkbp:UniProtID |
P43354
|
| gptkbp:bfsParent |
gptkb:NR4
gptkb:Nuclear_receptor_superfamily |
| gptkbp:bfsLayer |
7
|