Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
roof plate-specific spondins
|
| gptkbp:binds |
gptkb:LGR4
gptkb:LGR5 gptkb:LGR6 RNF43 ZNRF3 |
| gptkbp:discoveredIn |
2002
|
| gptkbp:domain |
furin-like cysteine-rich domain
thrombospondin type 1 domain |
| gptkbp:encodedBy |
RSPO genes
|
| gptkbp:expressedIn |
various tissues
|
| gptkbp:fullName |
gptkb:R-spondin_proteins
|
| gptkbp:function |
potentiate Wnt/β-catenin signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
RSPO proteins
|
| gptkbp:involvedIn |
gptkb:Wnt_signaling_pathway
|
| gptkbp:member |
gptkb:RSPO1
gptkb:RSPO2 gptkb:RSPO3 gptkb:RSPO4 |
| gptkbp:mutationAssociatedWith |
colorectal cancer
hepatocellular carcinoma palmoplantar keratoderma sex reversal anonychia |
| gptkbp:numberOfMembers |
4
|
| gptkbp:orthologIn |
gptkb:fish
birds amphibians mammals reptiles |
| gptkbp:proteinFamily |
gptkb:RSPO1
gptkb:RSPO2 gptkb:RSPO3 gptkb:RSPO4 |
| gptkbp:regulates |
cell differentiation
cell proliferation embryonic development angiogenesis bone formation cell fate determination tissue homeostasis gonadal development mammary gland development hair follicle stem cells intestinal stem cells |
| gptkbp:role |
cancer progression
tissue regeneration organ development stem cell regulation |
| gptkbp:bfsParent |
gptkb:R-spondin_proteins
|
| gptkbp:bfsLayer |
7
|