|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:RIR1
gptkb:RNR-1
gptkb:RR1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
cell proliferation
DNA synthesis
oxidoreductase activity
|
|
gptkbp:component
|
gptkb:ribonucleotide_reductase_complex
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171848
6240
|
|
gptkbp:enzymeCommissionNumber
|
1.17.4.1
|
|
gptkbp:essentialGene
|
yes
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Ribonucleoside-diphosphate_reductase_large_subunit
|
|
gptkbp:function
|
catalyzes the formation of deoxyribonucleotides from ribonucleotides
|
|
gptkbp:gene
|
gptkb:RRM1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO
|
gptkb:GO:0004748
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
10448
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RRM1
|
|
gptkbp:inhibitedBy
|
gptkb:hydroxyurea
gemcitabine
|
|
gptkbp:interactsWith
|
gptkb:RRM2
gptkb:p53
|
|
gptkbp:length
|
792 amino acids
|
|
gptkbp:locatedOnChromosome
|
11p15.4
|
|
gptkbp:molecularWeight
|
90 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause resistance to chemotherapy
|
|
gptkbp:OMIM
|
180570
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Rrm1
|
|
gptkbp:orthologInYeast
|
gptkb:RNR1
|
|
gptkbp:pathway
|
purine metabolism
pyrimidine metabolism
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:RefSeq
|
gptkb:NM_001033
|
|
gptkbp:regulates
|
cell cycle dependent
|
|
gptkbp:significance
|
predictive biomarker for gemcitabine response
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P23921
|
|
gptkbp:bfsParent
|
gptkb:11p15.5
|
|
gptkbp:bfsLayer
|
6
|