Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic alteration
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
gptkb:papillary_thyroid_carcinoma gptkb:cancer |
| gptkbp:cause |
oncogenic transformation
|
| gptkbp:commonFusionPartner |
gptkb:CCDC6
gptkb:KIF5B gptkb:NCOA4 |
| gptkbp:detects |
gptkb:fluorescence_in_situ_hybridization
next-generation sequencing |
| gptkbp:firstDescribed |
1987
|
| gptkbp:foundIn |
gptkb:cancer
solid tumors |
| gptkbp:frequencyInNSCLC |
1-2%
|
| https://www.w3.org/2000/01/rdf-schema#label |
RET gene fusion
|
| gptkbp:involvedIn |
gptkb:RET
|
| gptkbp:mechanismOfAction |
chromosomal rearrangement
|
| gptkbp:result |
constitutive activation of RET kinase
|
| gptkbp:target |
gptkb:pralsetinib
gptkb:selpercatinib |
| gptkbp:bfsParent |
gptkb:RET_fusion-positive_thyroid_cancer
|
| gptkbp:bfsLayer |
7
|