Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:genetic_alteration
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
gptkb:papillary_thyroid_carcinoma |
| gptkbp:cause |
uncontrolled cell proliferation
oncogenic signaling |
| gptkbp:detects |
gptkb:reverse_transcription_PCR
gptkb:fluorescence_in_situ_hybridization next-generation sequencing |
| gptkbp:firstDescribed |
gptkb:papillary_thyroid_carcinoma
|
| gptkbp:frequency_in_NSCLC |
1-2%
|
| gptkbp:frequency_in_papillary_thyroid_carcinoma |
10-20%
|
| gptkbp:involvedIn |
gptkb:RET
|
| gptkbp:mechanismOfAction |
gptkb:chromosomal_rearrangement
|
| gptkbp:partner_gene_example |
gptkb:CCDC6
gptkb:KIF5B gptkb:NCOA4 |
| gptkbp:result |
constitutive activation of RET kinase
|
| gptkbp:significance |
predictive biomarker for targeted therapy
|
| gptkbp:targetOfDrug |
gptkb:pralsetinib
gptkb:selpercatinib |
| gptkbp:bfsParent |
gptkb:RET_fusion-positive_thyroid_cancer
gptkb:RET_fusion-positive_cancers |
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
RET fusion
|