Statements (23)
Predicate | Object |
---|---|
gptkbp:instanceOf |
genetic alteration
|
gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
gptkb:papillary_thyroid_carcinoma |
gptkbp:cause |
uncontrolled cell proliferation
oncogenic signaling |
gptkbp:detects |
gptkb:reverse_transcription_PCR
gptkb:fluorescence_in_situ_hybridization next-generation sequencing |
gptkbp:firstDescribed |
gptkb:papillary_thyroid_carcinoma
|
gptkbp:frequency_in_NSCLC |
1-2%
|
gptkbp:frequency_in_papillary_thyroid_carcinoma |
10-20%
|
https://www.w3.org/2000/01/rdf-schema#label |
RET fusion
|
gptkbp:involvedIn |
gptkb:RET
|
gptkbp:mechanismOfAction |
chromosomal rearrangement
|
gptkbp:partner_gene_example |
gptkb:CCDC6
gptkb:KIF5B gptkb:NCOA4 |
gptkbp:result |
constitutive activation of RET kinase
|
gptkbp:significance |
predictive biomarker for targeted therapy
|
gptkbp:targetOfDrug |
gptkb:pralsetinib
gptkb:selpercatinib |
gptkbp:bfsParent |
gptkb:RET_fusion-positive_thyroid_cancer
|
gptkbp:bfsLayer |
7
|