Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
gptkb:gene_therapy
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:anemia gptkb:neurodegenerative_diseases ovarian cancer homologous recombination |
| gptkbp:binding_site |
ss DNA
|
| gptkbp:clinical_trial |
potential target for cancer treatment
|
| gptkbp:collaborates_with |
gptkb:BRCA1
|
| gptkbp:diseases |
gptkb:Oncology
|
| gptkbp:fauna |
gptkb:Anthropology
|
| gptkbp:function |
DNA repair
strand annealing DNA strand exchange facilitates homologous recombination mediates homologous recombination promotes DNA repair pathways promotes genetic recombination stabilizes DNA structures |
| gptkbp:genetic_studies |
increased genomic instability
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAD52 protein
|
| gptkbp:initiated_by |
under investigation
|
| gptkbp:interacts_with |
gptkb:BRCA2
gptkb:RAD51 RPA XPA |
| gptkbp:involved_in |
cell cycle regulation
DNA repair mechanisms chromosomal stability DNA repair pathways telomere maintenance double-strand break repair DNA damage signaling repair of double-strand breaks repair of single-strand breaks DNA replication stress response immunoglobulin class switch recombination repair of DNA crosslinks repair of interstrand crosslinks |
| gptkbp:is_expressed_in |
varies in different tissues
upregulated in response to DNA damage increased in tumor cells regulated by DNA damage response pathways regulated by p53 |
| gptkbp:location |
gptkb:Atom
|
| gptkbp:modifications |
phosphorylation
|
| gptkbp:orthologs |
found in various species
|
| gptkbp:pathway |
DNA repair pathway
|
| gptkbp:promoter |
gptkb:RAD52
|
| gptkbp:research_focus |
genomic stability
|
| gptkbp:role |
DNA damage response
cellular response to stress cellular repair processes genome integrity homologous recombination repair repair of oxidative DNA damage DNA damage tolerance |
| gptkbp:structure |
homotetrameric complex
|
| gptkbp:type |
recombinase
|
| gptkbp:weight |
approximately 52 k Da
|
| gptkbp:bfsParent |
gptkb:RAD52
|
| gptkbp:bfsLayer |
7
|