Protein kinase A catalytic subunit alpha

URI: https://gptkb.org/entity/Protein_kinase_A_catalytic_subunit_alpha
GPTKB entity
Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activatedBy cyclic AMP
gptkbp:alternativeName gptkb:PRKACA
C-alpha
gptkbp:associatedWith gptkb:Cushing's_syndrome
adrenocortical adenoma
gptkbp:biologicalProcess signal transduction
regulation of transcription
protein serine/threonine kinase activity
gptkbp:cellularComponent gptkb:nucleus
gptkb:cytoplasm
gptkbp:encodedBy PRKACA gene
gptkbp:Entrez_Gene_ID 5566
gptkbp:enzymeCommissionNumber EC 2.7.11.11
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function catalytic subunit of protein kinase A
gptkbp:HGNC_ID 9380
gptkbp:highestExpression brain
heart
https://www.w3.org/2000/01/rdf-schema#label Protein kinase A catalytic subunit alpha
gptkbp:inhibitedBy PKA regulatory subunit
gptkbp:interactsWith A-kinase anchoring proteins (AKAPs)
PKA regulatory subunit
gptkbp:length 350 amino acids
gptkbp:locatedOnChromosome gptkb:19p13.1
gptkbp:molecularWeight 40 kDa
gptkbp:OMIM 601639
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1ATP
3FJQ
4DFX
gptkbp:phosphorylates gptkb:CREB
gptkb:BAD
gptkb:glycogen_synthase_kinase_3
gptkb:phospholamban
gptkbp:postTranslationalModification phosphorylation
myristoylation
gptkbp:RefSeq NP_002721.1
gptkbp:regulates cell differentiation
metabolism
cell growth
memory formation
gptkbp:structure kinase domain
gptkbp:subunit protein kinase A holoenzyme
gptkbp:target H-89 (PKA inhibitor)
PKI (protein kinase inhibitor peptide)
gptkbp:UniProtID P17612
gptkbp:bfsParent gptkb:1PKN
gptkbp:bfsLayer 7