|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeTo
|
gptkb:26S_proteasome
gptkb:immunoproteasome
20S proteasome
hybrid proteasome
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:component
|
ubiquitin-proteasome system
|
|
gptkbp:degradedBy
|
regulatory proteins
misfolded proteins
short-lived proteins
|
|
gptkbp:discoveredBy
|
gptkb:Alfred_Goldberg
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:EC_number
|
3.4.25.1
|
|
gptkbp:encodedBy
|
multiple genes
|
|
gptkbp:energyEfficiency
|
ATP-dependent
|
|
gptkbp:foundIn
|
archaea
eukaryotic cells
some bacteria
|
|
gptkbp:function
|
gptkb:ubiquitin-proteasome_pathway
protein degradation
|
|
gptkbp:GO_term
|
GO:0000502
|
|
gptkbp:hasBiologicalActivity
|
gptkb:protease
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Proteasome
|
|
gptkbp:inhibitedBy
|
gptkb:carfilzomib
gptkb:bortezomib
gptkb:lactacystin
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:medicalUse
|
target for cancer therapy
target for multiple myeloma treatment
|
|
gptkbp:molecularWeight
|
about 2.5 MDa
|
|
gptkbp:PDB
|
1IRU
|
|
gptkbp:presentIn
|
all eukaryotes
some prokaryotes
|
|
gptkbp:relatedTo
|
E3 ubiquitin ligase
ubiquitin
protein homeostasis
|
|
gptkbp:role
|
apoptosis
cell cycle regulation
protein quality control
antigen processing
|
|
gptkbp:structure
|
barrel-shaped
|
|
gptkbp:substrate
|
ubiquitinated proteins
|
|
gptkbp:subunit
|
gptkb:19S_regulatory_particle
gptkb:20S_core_particle
|
|
gptkbp:UniProtID
|
P62333 (example subunit)
|
|
gptkbp:bfsParent
|
gptkb:R-HSA-5673003
gptkb:Peptidase
|
|
gptkbp:bfsLayer
|
7
|