Statements (84)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:ATP-dependent |
true
|
| gptkbp:component |
ubiquitin-proteasome system
|
| gptkbp:composedOf |
gptkb:19S_regulatory_particle
gptkb:20S_core_particle |
| gptkbp:determines |
cryo-electron microscopy
|
| gptkbp:discoveredBy |
gptkb:Alfred_Goldberg
|
| gptkbp:EC_number |
3.4.25.1
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
protein degradation
ubiquitin-dependent proteolysis |
| gptkbp:GO_term |
GO:0000502
|
| https://www.w3.org/2000/01/rdf-schema#label |
26S proteasome
|
| gptkbp:inhibitedBy |
gptkb:bortezomib
gptkb:lactacystin MG132 |
| gptkbp:locatedIn |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:molecularWeight |
~2.5 MDa
|
| gptkbp:role |
apoptosis
DNA repair cell cycle regulation protein quality control transcriptional regulation antigen processing |
| gptkbp:subunit |
gptkb:PSMB2
gptkb:PSMD4 gptkb:PSMA1 gptkb:PSMB1 gptkb:PSMC1 gptkb:PSMD1 PSME1 PSME2 PSME3 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB10 PSMB11 PSMB12 PSMB13 PSMB14 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME4 PSMF1 PSMG1 PSMG2 PSMG3 PSMG4 PSMG5 PSMG6 PSMG7 PSMG8 |
| gptkbp:subunitCount |
at least 33 distinct subunits
|
| gptkbp:UniProtID |
P62333 (example subunit)
|
| gptkbp:bfsParent |
gptkb:ubiquitin-proteasome_pathway
|
| gptkbp:bfsLayer |
7
|