Trithorax-group (TrxG) family
GPTKB entity
Statements (43)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
protein complex family
|
| gptkbp:amendedBy |
histone H3 lysine 4 (H3K4)
|
| gptkbp:associatedWith |
gene activation
chromatin remodeling |
| gptkbp:catalyzes |
H3K4 methylation
|
| gptkbp:conservedIn |
animals
|
| gptkbp:contains |
gptkb:MLL2
gptkb:MLL4 gptkb:ASH1 gptkb:MLL1 gptkb:Trithorax_(Trx) histone acetyltransferases MLL3 histone methyltransferases SET1A SET1B chromatin remodelers |
| gptkbp:discoveredBy |
gptkb:Drosophila_melanogaster
|
| gptkbp:enemyOf |
gene silencing
|
| gptkbp:firstDescribed |
1980s
|
| gptkbp:function |
transcriptional activation
epigenetic regulation |
| https://www.w3.org/2000/01/rdf-schema#label |
Trithorax-group (TrxG) family
|
| gptkbp:includes |
gptkb:CBP/p300
gptkb:SWI/SNF_complex COMPASS complex |
| gptkbp:mutationAssociatedWith |
leukemia
developmental defects |
| gptkbp:namedAfter |
Trithorax gene
|
| gptkbp:opposedBy |
gptkb:Polycomb-group_(PcG)_family
|
| gptkbp:regulates |
embryonic development
Hox gene expression cellular memory transcriptional memory |
| gptkbp:role |
gptkb:cancer
development cell fate determination stem cell maintenance |
| gptkbp:studiedBy |
mammals
plants flies |
| gptkbp:bfsParent |
gptkb:Polycomb-group_(PcG)_family
|
| gptkbp:bfsLayer |
8
|