Trithorax-group (TrxG) family

URI: https://gptkb.org/entity/Trithorax-group_(TrxG)_family
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:protein_complex_family
gptkbp:amendedBy histone H3 lysine 4 (H3K4)
gptkbp:associatedWith gene activation
chromatin remodeling
gptkbp:catalyzes H3K4 methylation
gptkbp:conservedIn animals
gptkbp:contains gptkb:MLL2
gptkb:MLL4
gptkb:ASH1
gptkb:MLL1
gptkb:Trithorax_(Trx)
histone acetyltransferases
MLL3
histone methyltransferases
SET1A
SET1B
chromatin remodelers
gptkbp:discoveredBy gptkb:Drosophila_melanogaster
gptkbp:enemyOf gene silencing
gptkbp:firstDescribed 1980s
gptkbp:function transcriptional activation
epigenetic regulation
gptkbp:includes gptkb:CBP/p300
gptkb:SWI/SNF_complex
COMPASS complex
gptkbp:mutationAssociatedWith gptkb:leukemia
developmental defects
gptkbp:namedAfter Trithorax gene
gptkbp:opposedBy gptkb:Polycomb-group_(PcG)_family
gptkbp:regulates embryonic development
Hox gene expression
cellular memory
transcriptional memory
gptkbp:role gptkb:cancer
development
cell fate determination
stem cell maintenance
gptkbp:studiedBy mammals
plants
flies
gptkbp:bfsParent gptkb:Polycomb-group_(PcG)_family
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label Trithorax-group (TrxG) family