Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:PTTG
Securin |
| gptkbp:associatedWith |
various cancers
pituitary tumors |
| gptkbp:biologicalProcess |
transcriptional regulation
inhibits separase activity prevents premature chromatid separation |
| gptkbp:degradedBy |
gptkb:anaphase-promoting_complex
|
| gptkbp:discoveredBy |
Pei L et al.
|
| gptkbp:discoveredIn |
1997
|
| gptkbp:encodes |
securin protein
|
| gptkbp:Entrez_Gene_ID |
9232
|
| gptkbp:expressedIn |
gptkb:pituitary_gland
various tumor tissues |
| gptkbp:fullName |
pituitary tumor-transforming gene 1
|
| gptkbp:function |
cell cycle regulation
transcriptional activation regulation of sister chromatid separation |
| gptkbp:HGNC_ID |
HGNC:9690
|
| https://www.w3.org/2000/01/rdf-schema#label |
PTTG1
|
| gptkbp:interactsWith |
gptkb:separase
gptkb:Ku70 gptkb:p53 |
| gptkbp:length |
202 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5
5q35.1 |
| gptkbp:mutationAssociatedWith |
tumorigenesis
|
| gptkbp:OMIM |
604147
|
| gptkbp:orthologInMouse |
Pttg1
|
| gptkbp:overexpressedIn |
tumorigenesis
cell transformation |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination |
| gptkbp:proteinFamily |
transactivation domain
C-terminal destruction box |
| gptkbp:regulates |
apoptosis
cell proliferation DNA repair angiogenesis cell migration invasion chromosome segregation p53 pathway genomic stability FGF2 expression |
| gptkbp:UniProtID |
O95997
|
| gptkbp:bfsParent |
gptkb:securin
|
| gptkbp:bfsLayer |
7
|