|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:PINK1
gptkb:BRPK
gptkb:PARK6
|
|
gptkbp:associatedWith
|
autosomal recessive inheritance
|
|
gptkbp:discoveredBy
|
gptkb:Valina_L._Dawson
|
|
gptkbp:encodedBy
|
gptkb:PINK1_gene
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
brain
heart
|
|
gptkbp:firstDescribed
|
2001
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
serine/threonine kinase activity
mitochondrial quality control
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:14581
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTEN-induced kinase 1
|
|
gptkbp:involves
|
gptkb:Parkinson's_disease
neuroprotection
mitophagy
response to oxidative stress
|
|
gptkbp:length
|
581
|
|
gptkbp:locale
|
mitochondria
|
|
gptkbp:locatedOnChromosome
|
1p36.12
|
|
gptkbp:molecularWeight
|
63 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:early-onset_Parkinson's_disease
|
|
gptkbp:OMIM
|
608309
|
|
gptkbp:orthologIn
|
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
gptkb:Parkin
ubiquitin
Ser228
Ser346
Ser402
Thr257
|
|
gptkbp:product
|
gptkb:PINK1_gene
|
|
gptkbp:regulates
|
apoptosis
cell survival
mitochondrial dynamics
mitochondrial fission
mitochondrial fusion
|
|
gptkbp:structure
|
contains kinase domain
contains mitochondrial targeting sequence
|
|
gptkbp:UniProtID
|
gptkb:Q9BXM7
|
|
gptkbp:bfsParent
|
gptkb:PARK6
|
|
gptkbp:bfsLayer
|
8
|