Statements (95)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
RNA polymerase II 220 kDa subunit
RNA polymerase II subunit RPB1 RPB1 |
| gptkbp:associatedWith |
gptkb:cancer
transcription regulation cellular response to DNA damage |
| gptkbp:biologicalProcess |
transcription by RNA polymerase II
DNA-directed RNA polymerase activity |
| gptkbp:cellularComponent |
gptkb:nucleus
|
| gptkbp:discoveredBy |
multiple researchers, 1980s
|
| gptkbp:encodes |
RNA polymerase II subunit A
|
| gptkbp:Entrez_Gene_ID |
5430
ENSG00000116044 |
| gptkbp:essentialGene |
true
|
| gptkbp:expressedIn |
most human tissues
|
| gptkbp:function |
catalytic subunit of RNA polymerase II
transcription of DNA to mRNA |
| gptkbp:hasCTD |
C-terminal domain (CTD) with heptapeptide repeats
|
| gptkbp:hasParalog |
gptkb:POLR2B
gptkb:POLR2C |
| gptkbp:HGNC_ID |
9173
|
| https://www.w3.org/2000/01/rdf-schema#label |
POLR2A
|
| gptkbp:interactsWith |
gptkb:CREBBP
gptkb:CDK9 gptkb:GTF2B gptkb:BRCA1 gptkb:TAF15 gptkb:TP53 GTF2F1 MED1 SUPT5H |
| gptkbp:length |
1970 amino acids
|
| gptkbp:locatedOnChromosome |
17
|
| gptkbp:mutationAssociatedWith |
intellectual disability
neurodevelopmental disorders |
| gptkbp:OMIM |
180660
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Polr2a
|
| gptkbp:phosphorylates |
CTD serine residues
|
| gptkbp:proteinFamily |
RNA polymerase II subunits
RNA_pol_Rpb1_1 RNA_pol_Rpb1_10 RNA_pol_Rpb1_11 RNA_pol_Rpb1_12 RNA_pol_Rpb1_13 RNA_pol_Rpb1_14 RNA_pol_Rpb1_15 RNA_pol_Rpb1_16 RNA_pol_Rpb1_17 RNA_pol_Rpb1_18 RNA_pol_Rpb1_19 RNA_pol_Rpb1_2 RNA_pol_Rpb1_20 RNA_pol_Rpb1_21 RNA_pol_Rpb1_22 RNA_pol_Rpb1_23 RNA_pol_Rpb1_24 RNA_pol_Rpb1_25 RNA_pol_Rpb1_26 RNA_pol_Rpb1_27 RNA_pol_Rpb1_28 RNA_pol_Rpb1_29 RNA_pol_Rpb1_3 RNA_pol_Rpb1_30 RNA_pol_Rpb1_31 RNA_pol_Rpb1_32 RNA_pol_Rpb1_33 RNA_pol_Rpb1_34 RNA_pol_Rpb1_35 RNA_pol_Rpb1_36 RNA_pol_Rpb1_37 RNA_pol_Rpb1_38 RNA_pol_Rpb1_39 RNA_pol_Rpb1_4 RNA_pol_Rpb1_40 RNA_pol_Rpb1_41 RNA_pol_Rpb1_42 RNA_pol_Rpb1_43 RNA_pol_Rpb1_44 RNA_pol_Rpb1_45 RNA_pol_Rpb1_46 RNA_pol_Rpb1_47 RNA_pol_Rpb1_48 RNA_pol_Rpb1_49 RNA_pol_Rpb1_5 RNA_pol_Rpb1_50 RNA_pol_Rpb1_6 RNA_pol_Rpb1_7 RNA_pol_Rpb1_8 RNA_pol_Rpb1_9 |
| gptkbp:RefSeq |
NM_000937
|
| gptkbp:UniProtID |
P24928
|
| gptkbp:bfsParent |
gptkb:RNA_polymerase_II
|
| gptkbp:bfsLayer |
7
|