|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
phorbol esters
|
|
gptkbp:alternativeSplicing
|
PKCβI
PKCβII
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:cofactor
|
calcium
lipoprotein
diacylglycerol
|
|
gptkbp:discoveredBy
|
gptkb:Yasutomi_Nishizuka
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:EC_number
|
2.7.11.13
|
|
gptkbp:encodedBy
|
PRKCB gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:B_lymphocytes
gptkb:kidney
brain
heart
pancreas
|
|
gptkbp:family
|
gptkb:protein_kinase_C_family
|
|
gptkbp:fullName
|
Protein kinase C beta
|
|
gptkbp:function
|
phosphorylation of serine and threonine residues
|
|
gptkbp:GO_term
|
gptkb:GO:0004697
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PKCβ
|
|
gptkbp:inhibitedBy
|
gptkb:enzastaurin
ruboxistaurin
|
|
gptkbp:involvedIn
|
gptkb:B_cell_receptor_signaling_pathway
signal transduction
immune response
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
77 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2I0E
|
|
gptkbp:phosphorylates
|
gptkb:histone_H1
gptkb:MARCKS
gptkb:myristoylated_alanine-rich_C-kinase_substrate
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
gptkb:C1_domain
kinase domain
C2 domain
|
|
gptkbp:substrate
|
proteins with serine/threonine residues
|
|
gptkbp:UniProtID
|
P05771
|
|
gptkbp:bfsParent
|
gptkb:B_cell_receptor_signaling_pathway
|
|
gptkbp:bfsLayer
|
7
|