phosphoglycerate kinase 1

URI: https://gptkb.org/entity/phosphoglycerate_kinase_1
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName PGK
PGK-1
cellular phosphoglycerate kinase
gptkbp:associatedWith phosphoglycerate kinase deficiency
X-linked recessive disorders
gptkbp:biologicalProcess ATP binding
glycolytic process
phosphoglycerate kinase activity
gptkbp:cellularComponent gptkb:cytoplasm
gptkbp:cofactor Mg2+
gptkbp:conserved_domain PGK domain
gptkbp:discoveredIn 1957
gptkbp:EC_number 2.7.2.3
gptkbp:Entrez_Gene_ID 5230
gptkbp:enzymeClassification transferase
gptkbp:expressedIn gptkb:skeletal_muscle
brain
erythrocytes
gptkbp:function catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP
gptkbp:gene gptkb:PGK1
gptkbp:geneType protein-coding
gptkbp:GO_term GO:0005737
GO:0006096
GO:0004618
gptkbp:hasIsoform gptkb:phosphoglycerate_kinase_2
gptkbp:HGNC_ID 8896
https://www.w3.org/2000/01/rdf-schema#label phosphoglycerate kinase 1
gptkbp:length 417
gptkbp:locatedOnChromosome gptkb:X_chromosome
Xq13.3
gptkbp:molecularWeight 44.5 kDa
gptkbp:OMIM 300653
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn phosphoglycerate kinase 1 (mouse)
gptkbp:pathway glycolysis
gptkbp:PDB gptkb:2XE7
gptkbp:product gptkb:ATP
gptkb:3-phosphoglycerate
gptkbp:proteinFamily phosphoglycerate kinase family
gptkbp:RefSeq NM_000291
gptkbp:regulates hypoxia-inducible
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:significance mutations cause hemolytic anemia
gptkbp:structure monomer
gptkbp:substrate gptkb:ADP
1,3-bisphosphoglycerate
gptkbp:tissue_specificity ubiquitous
gptkbp:UniProtID gptkb:P00558
gptkbp:bfsParent gptkb:PGK1
gptkbp:bfsLayer 8