|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:purinergic_receptor_P2Y,_G-protein_coupled,_12
|
|
gptkbp:associatedWith
|
myocardial infarction
stroke
thrombosis
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:encodedBy
|
gptkb:P2RY12_gene
|
|
gptkbp:enemyOf
|
gptkb:ticagrelor
gptkb:clopidogrel
gptkb:prasugrel
gptkb:cangrelor
gptkb:ticlopidine
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000169313
GC03M148282
|
|
gptkbp:expressedIn
|
gptkb:microglia
gptkb:megakaryocytes
|
|
gptkbp:foundIn
|
gptkb:human
platelets
|
|
gptkbp:function
|
mediates platelet aggregation
|
|
gptkbp:HGNC_ID
|
15585
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P2Y12 receptor
|
|
gptkbp:ligand
|
gptkb:ADP
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q25.2
|
|
gptkbp:memberOf
|
purinergic receptor family
|
|
gptkbp:OMIM
|
609821
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:pharmacogenomics
|
CYP2C19 polymorphism affects response
|
|
gptkbp:RefSeq
|
NM_022788
|
|
gptkbp:relatedTo
|
gptkb:cardiovascular_disease
hemostasis
ischemic events
|
|
gptkbp:structureType
|
seven transmembrane domain protein
|
|
gptkbp:target
|
antiplatelet drugs
|
|
gptkbp:targetOfDrug
|
gptkb:acute_coronary_syndrome
percutaneous coronary intervention
prevention of stent thrombosis
secondary prevention of stroke
|
|
gptkbp:type
|
inhibits adenylyl cyclase via Gi protein
|
|
gptkbp:UniProtID
|
Q9H244
|
|
gptkbp:bfsParent
|
gptkb:AR-C
|
|
gptkbp:bfsLayer
|
6
|