|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CLMF2
gptkb:Interleukin-12_subunit_beta
gptkb:NKSF2
Cytokine p40 subunit
Natural killer cell stimulatory factor 2
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
asthma
multiple sclerosis
psoriasis
|
|
gptkbp:biologicalProcess
|
immune response
cytokine activity
|
|
gptkbp:component
|
gptkb:Interleukin-12
Interleukin-23
|
|
gptkbp:disulfideBond
|
present
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000264434
GC12P002178
|
|
gptkbp:expressedIn
|
gptkb:B_cells
dendritic cells
macrophages
|
|
gptkbp:function
|
forms heterodimer with IL12A to make IL-12
forms heterodimer with IL23A to make IL-23
|
|
gptkbp:gene
|
gptkb:IL12B
|
|
gptkbp:GO_term
|
gptkb:GO:0006955_(immune_response)
GO:0005125 (cytokine activity)
|
|
gptkbp:HGNC_ID
|
HGNC:5969
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P29460 (IL12B)
|
|
gptkbp:involves
|
T cell differentiation
NK cell activation
|
|
gptkbp:locatedOnChromosome
|
5q33.3
|
|
gptkbp:location
|
secreted
|
|
gptkbp:molecularWeight
|
37.3 kDa
|
|
gptkbp:OMIM
|
161561
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
1F45
3DUH
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:proteinFamily
|
PF00722 (IL12p40)
PF16649 (IL12p40_C)
|
|
gptkbp:RefSeq
|
NP_002178.2
|
|
gptkbp:sequence
|
328 amino acids
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:subunit
|
p40
|
|
gptkbp:UniProt_reviewed
|
yes
|
|
gptkbp:UniProtID
|
gptkb:P29460
|
|
gptkbp:bfsParent
|
gptkb:Interleukin-12
|
|
gptkbp:bfsLayer
|
8
|