Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:associatedWith |
gptkb:cancer
infectious diseases autoimmune diseases |
| gptkbp:category |
cytokine
|
| gptkbp:composedOf |
gptkb:IL-12A
gptkb:IL-12B |
| gptkbp:discoveredIn |
1989
|
| gptkbp:function |
induces production of interferon-gamma
stimulates differentiation of naive T cells into Th1 cells enhances cytotoxic activity of natural killer cells |
| https://www.w3.org/2000/01/rdf-schema#label |
Interleukin-12
|
| gptkbp:involvedIn |
inflammation
immune response |
| gptkbp:locatedOnChromosome |
chromosome 3 (IL12A)
chromosome 5 (IL12B) |
| gptkbp:producedBy |
dendritic cells
macrophages |
| gptkbp:promotion |
IFN-gamma production
TNF-alpha production |
| gptkbp:recipient |
gptkb:IL-12_receptor
|
| gptkbp:regulates |
T cell activity
NK cell activity |
| gptkbp:structure |
heterodimeric protein
|
| gptkbp:subunit |
p35
p40 |
| gptkbp:symbol |
gptkb:IL-12
|
| gptkbp:target |
therapeutic antibodies
|
| gptkbp:UniProtID |
gptkb:P29459_(IL12A)
gptkb:P29460_(IL12B) |
| gptkbp:bfsParent |
gptkb:Il-12
|
| gptkbp:bfsLayer |
7
|